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risk","value":0.2375588568402554},{"note":"","symbol":"w_9","unit":"","value":17.719748212854313},{"note":"10 (10)","symbol":"y_10","unit":"log relative risk","value":-1.3713448034727846},{"note":"erro-padr\u00e3o publicado","symbol":"ep_10","unit":"log relative risk","value":0.2702310004663212},{"note":"","symbol":"w_10","unit":"","value":13.693979133979813},{"note":"11 (11)","symbol":"y_11","unit":"log relative risk","value":-0.33935882833839015},{"note":"erro-padr\u00e3o publicado","symbol":"ep_11","unit":"log relative risk","value":0.1114101161096232},{"note":"","symbol":"w_11","unit":"","value":80.56580415801031},{"note":"12 (12)","symbol":"y_12","unit":"log relative risk","value":0.4459134005713783},{"note":"erro-padr\u00e3o publicado","symbol":"ep_12","unit":"log relative risk","value":0.7297299810204818},{"note":"","symbol":"w_12","unit":"","value":1.8779136586268463},{"note":"13 (13)","symbol":"y_13","unit":"log relative 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\u0233_F)\u00b2 + w_2\u00b7(y_2 \u2212 \u0233_F)\u00b2 + w_3\u00b7(y_3 \u2212 \u0233_F)\u00b2 + w_4\u00b7(y_4 \u2212 \u0233_F)\u00b2 + w_5\u00b7(y_5 \u2212 \u0233_F)\u00b2 + w_6\u00b7(y_6 \u2212 \u0233_F)\u00b2 + w_7\u00b7(y_7 \u2212 \u0233_F)\u00b2 + w_8\u00b7(y_8 \u2212 \u0233_F)\u00b2 + w_9\u00b7(y_9 \u2212 \u0233_F)\u00b2 + w_10\u00b7(y_10 \u2212 \u0233_F)\u00b2 + w_11\u00b7(y_11 \u2212 \u0233_F)\u00b2 + w_12\u00b7(y_12 \u2212 \u0233_F)\u00b2 + w_13\u00b7(y_13 \u2212 \u0233_F)\u00b2","result":152.2330080823734,"terms":[],"text_pt":"A estat\u00edstica Q mede quanto os estudos discordam da m\u00e9dia de efeitos fixos al\u00e9m do acaso.","unit":""},{"formula":"C = (w_1 + w_2 + w_3 + w_4 + w_5 + w_6 + w_7 + w_8 + w_9 + w_10 + w_11 + w_12 + w_13) \u2212 (w_1\u00b2 + w_2\u00b2 + w_3\u00b2 + w_4\u00b2 + w_5\u00b2 + w_6\u00b2 + w_7\u00b2 + w_8\u00b2 + w_9\u00b2 + w_10\u00b2 + w_11\u00b2 + w_12\u00b2 + w_13\u00b2) / (w_1 + w_2 + w_3 + w_4 + w_5 + w_6 + w_7 + w_8 + w_9 + w_10 + w_11 + w_12 + w_13)","result":454.18088060405427,"terms":[],"text_pt":"C \u00e9 a constante de escala de DerSimonian e Laird.","unit":""},{"formula":"\u03c4\u00b2 = max(0, (Q \u2212 (k \u2212 1)) / C)","result":0.30876026286237646,"terms":[{"note":"","symbol":"k","unit":"estudos","value":13.0}],"text_pt":"A vari\u00e2ncia entre estudos \u03c4\u00b2 \u00e9 zero quando Q n\u00e3o excede k \u2212 1, o que o acaso sozinho produziria.","unit":"(log relative risk)\u00b2"},{"formula":"I\u00b2 = max(0, (Q \u2212 (k \u2212 1)) / Q) \u00d7 100","result":92.11734685456207,"terms":[],"text_pt":"I\u00b2 \u00e9 a parcela da dispers\u00e3o observada que vem da varia\u00e7\u00e3o entre estudos, n\u00e3o do acaso.","unit":"%"},{"formula":"w*_1 = 1 / (ep_1\u00b2 + \u03c4\u00b2) ; w*_2 = 1 / (ep_2\u00b2 + \u03c4\u00b2) ; w*_3 = 1 / (ep_3\u00b2 + \u03c4\u00b2) ; w*_4 = 1 / (ep_4\u00b2 + \u03c4\u00b2) ; w*_5 = 1 / (ep_5\u00b2 + \u03c4\u00b2) ; w*_6 = 1 / (ep_6\u00b2 + \u03c4\u00b2) ; w*_7 = 1 / (ep_7\u00b2 + \u03c4\u00b2) ; w*_8 = 1 / (ep_8\u00b2 + \u03c4\u00b2) ; w*_9 = 1 / (ep_9\u00b2 + \u03c4\u00b2) ; w*_10 = 1 / (ep_10\u00b2 + \u03c4\u00b2) ; w*_11 = 1 / (ep_11\u00b2 + \u03c4\u00b2) ; w*_12 = 1 / (ep_12\u00b2 + \u03c4\u00b2) ; w*_13 = 1 / (ep_13\u00b2 + \u03c4\u00b2)","result":null,"terms":[{"note":"","symbol":"w*_1","unit":"","value":1.5764291608993408},{"note":"","symbol":"w*_2","unit":"","value":1.9867231888137737},{"note":"","symbol":"w*_3","unit":"","value":1.3809708847338356},{"note":"","symbol":"w*_4","unit":"","value":3.0416373252818607},{"note":"","symbol":"w*_5","unit":"","value":2.7780059212670714},{"note":"","symbol":"w*_6","unit":"","value":3.167906508691391},{"note":"","symbol":"w*_7","unit":"","value":1.8804856925644875},{"note":"","symbol":"w*_8","unit":"","value":3.1977299477781354},{"note":"","symbol":"w*_9","unit":"","value":2.7382670687580495},{"note":"","symbol":"w*_10","unit":"","value":2.619274859084015},{"note":"","symbol":"w*_11","unit":"","value":3.113591830339357},{"note":"","symbol":"w*_12","unit":"","value":1.1886845201728637},{"note":"","symbol":"w*_13","unit":"","value":2.630437319945124}],"text_pt":"Os pesos de efeitos aleat\u00f3rios somam \u03c4\u00b2 \u00e0 vari\u00e2ncia de cada estudo, o que aproxima os pesos entre si quando os estudos discordam.","unit":""},{"formula":"ep(\u0233) = \u221a(1 / (w*_1 + w*_2 + w*_3 + w*_4 + w*_5 + w*_6 + w*_7 + w*_8 + w*_9 + w*_10 + w*_11 + w*_12 + w*_13))","result":0.1787420895354032,"terms":[],"text_pt":"O erro-padr\u00e3o da m\u00e9dia agrupada vem da soma dos pesos de efeitos aleat\u00f3rios.","unit":"log relative risk"},{"formula":"\u0233 = (w*_1\u00b7y_1 + w*_2\u00b7y_2 + w*_3\u00b7y_3 + w*_4\u00b7y_4 + w*_5\u00b7y_5 + w*_6\u00b7y_6 + w*_7\u00b7y_7 + w*_8\u00b7y_8 + w*_9\u00b7y_9 + w*_10\u00b7y_10 + w*_11\u00b7y_11 + w*_12\u00b7y_12 + w*_13\u00b7y_13) / (w*_1 + w*_2 + w*_3 + w*_4 + w*_5 + w*_6 + w*_7 + w*_8 + w*_9 + w*_10 + w*_11 + w*_12 + w*_13)","result":-0.7141172220732269,"terms":[],"text_pt":"A m\u00e9dia agrupada \u00e9 a m\u00e9dia das estimativas ponderada pelos pesos de efeitos aleat\u00f3rios.","unit":"log relative risk"},{"formula":"IC95 = \u0233 \u00b1 z\u00b7ep(\u0233)","result":null,"terms":[{"note":"quantil 0.975 da normal padr\u00e3o","symbol":"z","unit":"","value":1.959963984540054}],"text_pt":"O intervalo de 95% usa o valor cr\u00edtico da normal.","unit":""}]},"key":"pooled","label":"Random-effects pooled estimate (DerSimonian\u2013Laird) over 13 studies","se":0.1787420895354032,"unit":"log relative risk","value":-0.7141172220732269}],"notes":"","reason":"","status":"ok","tables":{"studies":[{"estimate":-0.8893113339202054,"id":"1","se":0.5706003548929508,"se_source":"reported","study_id":"1","weight_fixed":3.0713967835314193,"weight_pct":5.036491683231727,"weight_random":1.5764291608993408},{"estimate":-1.5853886572014306,"id":"2","se":0.4411135017182583,"se_source":"reported","study_id":"2","weight_fixed":5.13924471610913,"weight_pct":6.347329182641975,"weight_random":1.9867231888137737},{"estimate":-1.348073148299693,"id":"3","se":0.644490469571091,"se_source":"reported","study_id":"3","weight_fixed":2.407503908285565,"weight_pct":4.41202722473061,"weight_random":1.3809708847338356},{"estimate":-1.4415511900213054,"id":"4","se":0.14145681992130169,"se_source":"reported","study_id":"4","weight_fixed":49.97493281795706,"weight_pct":9.717646356814289,"weight_random":3.0416373252818607},{"estimate":-0.2175473222112957,"id":"5","se":0.2262966463950159,"se_source":"reported","study_id":"5","weight_fixed":19.52737039601342,"weight_pct":8.875377381656724,"weight_random":2.7780059212670714},{"estimate":-0.786115585818864,"id":"6","se":0.08310005087789514,"se_source":"reported","study_id":"6","weight_fixed":144.80962224959802,"weight_pct":10.121060419345175,"weight_random":3.167906508691391},{"estimate":-1.6208982235983924,"id":"7","se":0.4722470196542432,"se_source":"reported","study_id":"7","weight_fixed":4.483958128286655,"weight_pct":6.007913825721248,"weight_random":1.8804856925644875},{"estimate":0.011952333523841173,"id":"8","se":0.06294107798423641,"se_source":"reported","study_id":"8","weight_fixed":252.42458242622047,"weight_pct":10.216342533284292,"weight_random":3.1977299477781354},{"estimate":-0.4694176487381487,"id":"9","se":0.2375588568402554,"se_source":"reported","study_id":"9","weight_fixed":17.719748212854313,"weight_pct":8.748416776558122,"weight_random":2.7382670687580495},{"estimate":-1.3713448034727846,"id":"10","se":0.2702310004663212,"se_source":"reported","study_id":"10","weight_fixed":13.693979133979813,"weight_pct":8.368251724263134,"weight_random":2.619274859084015},{"estimate":-0.33935882833839015,"id":"11","se":0.1114101161096232,"se_source":"reported","study_id":"11","weight_fixed":80.56580415801031,"weight_pct":9.947531895144719,"weight_random":3.113591830339357},{"estimate":0.4459134005713783,"id":"12","se":0.7297299810204818,"se_source":"reported","study_id":"12","weight_fixed":1.8779136586268463,"weight_pct":3.7976966224232367,"weight_random":1.1886845201728637},{"estimate":-0.017313948216879493,"id":"13","se":0.26721650339001574,"se_source":"reported","study_id":"13","weight_fixed":14.004688271405163,"weight_pct":8.403914374184746,"weight_random":2.630437319945124}]},"tool":"evidence.pool_dl","version":"0.1.0","warnings":["I\u00b2 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